Industry Projects
Computationally designed promoters for pig humanization
eGenesis
I computationally designed promoters to drive pig pan-tissue transgene expression by identifying pan-expressed genes, generating synthetic promoters, and testing their activity. I demonstrated through experimental and computational analyses that our promoters were tissue-specific — a key finding that reframed the silencing hypothesis and contributed to the first compassionate use pig-to-human kidney transplant.
Methods: RNA-seq · ATAC-seq · PHASTcons
Analyses of cellular programming in aging
Altos Labs
As Sr. Computational Scientist, I led a matrixed team of four wet-lab scientists to perform translational studies of cellular programming. I developed computational pipelines to study the mechanism of action of our molecule of interest, designed experiments to test our hypotheses, and oversaw their execution.
Methods: Single-cell RNA-seq · Tool development · Cross-functional leadership
Multimodal AI initiatives
Altos Labs
I conceptualized and led the formation of a cross-functional team to develop multimodal machine learning models. I led the team through model development, training data collection, and experimental methods.
Methods: AI/ML development · Cross-functional leadership
Talks
- Worm Meeting 2021 — View PDF
- Transcriptomes as Phenotypes — ASBMB, May 2019 — View PDF
- Transcriptomes as Phenotypes — ASBMB, May 2018 — View PDF
- Hanna H. Gray Fellowship — HHMI — Talk PDF · Script PDF
Outreach
Clubes de Ciencia México
I have been an active participant, contributor, and instructor with Clubes de Ciencia, a graduate-student-led initiative that brings intensive science workshops to students across Mexico. My workshops have covered genetics, molecular biology, and evolutionary biology. I co-discovered a new planarian species — Dugesia guanajuatensis — with students during a 2016 workshop in Guanajuato. Full story →