Current Work
Exo-organs
Genesis
An exo-organ is a biohybrid device — complex, solid living tissue inside hardware, performing the physiological functions of a failing organ. We are building them at Genesis.
Previous Work
Analyses of cellular programming in aging
Altos Labs
I led a team of wet-lab and computational scientists studying the mechanism of action of a partial reprogramming molecule of interest — building analysis pipelines, designing experiments, and interpreting results across modalities.
Methods: Single-cell RNA-seq · Perturbational genomics · Tool development
Multimodal AI initiatives
Altos Labs
I assembled and led a team to develop multimodal machine learning models integrating genomics and imaging data to study biological aging.
Methods: Multimodal ML · Genomics · Imaging
Computationally designed promoters for pig humanization
eGenesis
I established the computational biology core at eGenesis and designed promoters for stable, pan-tissue transgene expression in pigs. These promoters were experimentally validated and used in the first pig-to-human kidney transplant.
Methods: RNA-seq · ATAC-seq · PHASTcons
Transcriptomes as phenotypes
Caltech · MIT
My doctoral and postdoctoral research established transcriptomes — genome-wide gene expression profiles — as quantitative phenotypes in C. elegans and bacteria. This framework, for reading biological state from gene expression rather than morphology, is the computational foundation the later work builds on.
Methods: RNA-seq · Statistical genetics · Mathematical modeling